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KMID : 0931320130130010036
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대한상부위장관.헬리코박터학회지
2013 Volume.13 No. 1 p.36 ~ p.43
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Four Endoscopic Predictors of Carcinoma as a Final Diagnosis after Endoscopic Resection of Forceps Biopsy-proven Gastric Adenomas
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Song Jun-Young
Lee Hae-Won
Cho Eun-Ju
Heo Jae-Joon
Jang Gook-Hwan
Park Seun-Ja
Park Moo-In
Moon Won
Jang Hee-Kyung
Kim Hyung-Hun
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Abstract
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Background/Aims: Previous studies have reported that the frequency of re-diagnosing as carcinoma after endoscopic resection of gastric adenoma ranges between 6% and 47%. Therefore, specific endoscopic findings have been used to predict re-diagnosing as carcinoma after endoscopic resection of gastric adenoma at our center. We evaluated whether there is a use for these indicators for predicting carcinoma as a final diagnosis in forceps biopsy-proven adenomas.
Materials and Methods: We investigated 378 tissue samples from 308 patients. Classification of specimens as adenoma and carcinoma was based on postresection specimen. Endoscopic findings were reviewed for tumor location, size, gross appearance, surface nodularity, central concavity, surface color, and presence of ulcers. These variables were analyzed and compared between the adenoma group (275 cases) and the carcinoma group (103 cases), assigned based on post-resection diagnosis.
Results: The mean patient age was 61, and 227 of the patients were male. The mean lesion diameter was 14.9±8.1 mm in the adenoma group and 17.9±9.3 mm in the carcinoma group. A lesion size of 15 mm or greater, depressed appearance, surface nodularity, central concavity, and presence of high-grade dysplasia were all independently associated with re-diagnosing as carcinoma after endoscopic resection.
Conclusions: Lesion size of 15 mm or greater, depressed-type appearance, central concavity, and nodular surface are feasible predictors of carcinoma as a final diagnosis in forceps biopsy-proven adenomas. Physicians need to recommend immediate endoscopic resection for forceps biopsy-proven adenomas with these four independent features so as not to miss the optimal window for treatment.
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KEYWORD
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Stomach, Adenoma, Carcinoma, Endoscopic, Treatment
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